Carboxamide Cilastatin Intermediate is a medication used to prevent the inactivation of the antibiotic drug imipenem by the human enzyme dehydropeptidase-I (DHP-I). The synthesis of cilastatin involves the use of several intermediates, including a carboxamide intermediate. The carboxamide intermediate used in the synthesis of cilastatin is typically prepared from N,N-diisopropylcarbodiimide (DIC), benzyl alcohol, and tert-butyl carbamate. The reaction between these reagents leads to the formation of a benzyl tert-butyl carbamate intermediate, which is then subjected to further reactions to obtain the desired carboxamide intermediate. Carboxamide Cilastatin Intermediate plays a crucial role in the synthesis of cilastatin, as it serves as a precursor to the final compound.
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