R - (-)- 3-Carbamoy Methyl-5-Methyl Hexanoic Acid is an organic compound with the molecular formula C10H19NO3. It is a chiral derivative of valproic acid, which is commonly used as an anticonvulsant and mood stabilizer medication. The compound can be synthesized from L-leucine by a series of reactions including oxidation, conversion to a nitrile, and hydrolysis of the nitrile to yield the carboxylic acid. The final step involves conversion of the carboxylic acid to the carbamoyl methyl ester using a coupling reagent such as dicyclohexylcarbodiimide (DCC) and N-hydroxysuccinimide (NHS), followed by deprotection of the ester with a base such as sodium hydroxide. R - (-)- 3-Carbamoy Methyl-5-Methyl Hexanoic Acid is a white to off-white crystalline powder that is sparingly soluble in water and soluble in organic solvents.
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